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New Era in Precision Medicine – Tumour Agnostic Treatment and Liquid Biopsy

New Era in Precision Medicine – Tumour Agnostic Treatment and Liquid Biopsy

Video Summary

1.The value of tumor agnostic cancer therapy:
a- The principle of “tumor agnostic”
b- How could this approach meet unmet medical needs?
-Increase patient pool: grouped with all forms of cancer featuring target genomic alterations
– Provide treatment options regardless of the frequency or location of cancer or cancers where treatment options are limited or not exist at all.
– Inform diagnosis while identifying potential therapeutic targets in one go. Understand the dynamics of disease progression and treatment response
– Ensure treatments highly targeted to individual cancer; increase response, reduces side effects compared to non-targeted standards of care.
– Avoid misdiagnosis which can lead to delays of diagnosis and treatment, reduces inefficiencies, reduces burden on healthcare system and bring potential savings.
– Help patients with more common forms of cancer, who have undergone numerous treatment options but unable to tolerate conventional therapy; those with later stages of cancer progression

2. NTRK epidemiology, clinical evidence of NTRK fusion-positive tumors and TRKi data
a- Efficacy and safety of TRKi use in patients with NTRK fusion-positive tumors.
b- Clinically meaningful benefits of TRKi and its performance on NTRK fusion-positive solid tumors:
-Individual patient responses across different tumor type
-Individual patient responses by CNS metastases and non-CNS metastases, intracranial responses vs systemic responses.
-Individual patient responses by type of NTRK gene
-Duration of response, PFS and OS

3. Larotrectinib – ASCO 2020 Update

4. Selection of a High Quality Next Generation Sequencing (NGS)

5. How FDA and CDx claim affects the test selection?
a- Clinicians’ perspectives on rare mutations testing with NGS (e.g. NTRK, ROS-1, BRAF).
-The concept of “Basket trials”. How it helps to target rare genomic alterations?
-How high-quality NGS across tumour types could serve a great job for genomic alteration identification?
-How well it aligns with precision oncology?
b. Criteria for selecting NGS testing:
– Advise and experience on gene penal selection in corresponding with clinical or oncological requirements?
– How to strike a balance between needs and cost?

6. Liquid Biopsy – applications

7. Clinical Benefit using Liquid Biopsy – Carcinoma of Unknown Primary (CUP)
8. Liquid Biopsy Experience Sharing – Case sharing


(Appreciation Acknowledgement: This educational program is supported by Roche Hong Kong Limited.)

Related videos

•  Next Generation Sequencing in Liquid Biopsy for Cancer Management
Dr. William CHO|Chartered Scientist (UK)

•“Unlocking the Potential of Precision Medicine” Panel Discussion
– Dr. William CHO|Chartered Scientist (UK) &
– Dr. Joseph Siu-Kie AU| Specialist in Clinical Oncology and President of Hong Kong Precision Oncology Society

For doctors to ask questions

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